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QUICK ANSWER
"Quién sabe" is a form of "quién sabe", a phrase which is often translated as "who knows". "Pues" is a conjunction which is often translated as "then". Learn more about the difference between "quién sabe" and "pues" below.
pues(
pwehs
)A conjunction is a word that connects words, phrases, clauses, or sentences (e.g., The cat and the dog slept.).
a. then
Estoy cansado. - Pues vete a dormir.I am tired. - Go to sleep then.
No sé qué decirte, pues.I don't know what to tell you, then.
2. (emphatic)